Vol. 22 No. 3 (2009), Artykuły
Vol. 22 No. 3 (2009)

Influence of acute administration of diazepam and novelanxiolytic Selank on rabbits’ spontaneous behaviour

Artykuły
Published 2009-09-30
Beata Cygan
Department of Human Physiology, Medical University of Lublin, Poland
Róża Czabak-Garbacz
Department of Human Physiology, Medical University of Lublin, Poland
Mariusz Teter
Department of Human Physiology, Medical University of Lublin, Poland
Mariusz Chomicki
Department of Human Physiology, Medical University of Lublin, Poland
Igor Kozlovsky
Institute of Pharmacology, Russian Academy of Medical Sciences, Russia

Abstract

The present study compared effects of the CBR agonist diazepam and a synthetic analog of tuftsin Selank on six forms of rabbits’ spontaneous behaviour. The experiments were performed in 2 groups of animals. In the first group diazepam was injected intravenously at a dose of 1 mg/kg, in the other Selank was administered intranasally at a dose of 200 μg/kg. Each daily session lasted 2h. Diazepam reduced orientation-searching reactions and food uptake and it prolonged the comfort phase. Tuftsin analog did not influence the examined reactions.

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