Abstract
The binding of drugs to melanin may have significant pharmacologic consequences. In spite of many investigations into the nature of drug binding to melanin, the exact mechanism of this interaction remains unknown. The aim of the presented work was to examine the interaction of antiarrythmic drugs with melanin in the presence of copper and zinc ions. It was demonstrated that the analyzed drugs form complexes with melanin biopolymer. It was also shown that Cu2+ and Zn2+ ions administered to melanin before complexing with drugs decrease the total amount of quinidine, disopyramide and metoprolol bound to melanin.
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