Abstract
The effects of 10-day treatment of rodents with Ukrain and imipramine (IMI) on selected biochemical parameters indicating liver functioning have been investigated. In blood serum of the animals AST and ALT activities, total protein and α-fetoprotein (AFP) levels were determined. The results show that10-day combined treatment with Ukrain and IMI significantly increased AFP (only in mice) and total protein in all rodents. The combined administration of Ukrain and IMI significantly decreased the activities of both AST and ALT only in mice serum. Therefore, a combined administration of Ukrain and IMI to rodents caused adverse changes in the examined biochemical parameters, which may indicate hepatotoxic interaction between these drugs.
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