Effects of NOS inhibitors and a NO precursor on the expression of tolerance to diazepam-induced motor impairment in mice

Authors

  • Jolanta Orzelska Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin Author
  • Sylwia Talarek Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin Author
  • Joanna Listos Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin Author https://orcid.org/0000-0002-5103-1830
  • Sylwia Fidecka Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin Author

DOI:

https://doi.org/10.12923/

Abstract

The effect of nonselective NOS inhibitors: NG-nitro-L-arginine (L-NOARG) and NG-nitro-L-arginine methyl ester (L-NAME) and a NO precursor, L-arginine on the expression of tolerance to the diazepam (DZ)-induced motor impairment was investigated in this study. The DZ-induced incoordination was assessed using the rotarod and chimney tests, on the 1st and 10th days of the experiment. L-NOARG and L-NAME were found to attenuate the expression of tolerance to the motor impairing effect of DZ. The lack of influence of L-arginine on the expression of tolerance to the DZ-induced motor impairment was observed in the present experiments. These results suggest that NO may be involved, at least in part, in the tolerance to the motor dysfunction induced by BZ.

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Annales Sectio DDD, XXIII, 1

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2025-04-04

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Vol. 23 No. 1 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

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