The influence of subinhibitory concentrations of quinupristin/dalfopristin, linezolid or vancomycin on slime production by Staphylococcus epidermidis
DOI:
https://doi.org/10.12923/Keywords:
Staphylococcus epidermidis, slime production, quinupristin/dalforpistin, linezolid, vancomycin, subinhibitory concentrationAbstract
One of the most important factors involved in biofilm formation of Staphylococcus epidermidis is the ability of slime production, creating a system for trapping nutrients and protecting bacterial cells with the biofilm against activity of antibiotics and immune system. The aim of this study was to assess the influence of some antibiotics on ability of slime production by S. epidermidis. We found that quinupristin/dalfopristin, linezolid and vancomycin inhibited slime production by S. epidermidis at subinhibitory concentrations in the following order – vancomycin < linezolid < quinupristin/dalfopristin. Our data suggest that these antibiotics, especially vancomycin, may be considered as factors interferring directly in slime production and thereby indirectly in biofilm formation of S. epidermidis.
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