Synthesis of phenoxazinone-type pharmaceutical compounds by fungal biomass
DOI:
https://doi.org/10.12923/Keywords:
phenoxazinone, antibiotics, biotransformation, Fomes fomentarius, laccaseAbstract
The phenoxazinone-type compound was achieved by transformation of 3-amino-4-hydroxybenzenesulfonic acid (AHBS) using fungus Fomes fomentarius (FF25). The oxidation of three different concentrations of AHBS was prepared in four transformation media differing in the concentration of carbon and nitrogen sources. The lower concentration of AHBS was transformed by immobilized fungal biomass even when the strain was incubated in water or in buffer. The product of this biotransformation belongs to phenoxazinone-type structures which are present in many pharmaceuticals.
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