Mushrooms from genus Clitocybe and Tricholoma as potential new sources of CNS-active agents

Authors

  • Krzysztof Grzywnowicz Department of Biochemistry, Maria Curie-Skłodowska University Author
  • Zuzanna Bielak Department of Biochemistry, Maria Curie-Skłodowska University Author
  • Kevin Lewellyn Department of Pharmacognosy, University of Mississippi, USA Author
  • Jordan Zjawiony Department of Pharmacognosy, University of Mississippi, USA Author https://orcid.org/0000-0001-5242-2799
  • Magdalena Jaszek Department of Biochemistry, Maria Curie-Skłodowska University Author https://orcid.org/0000-0003-2609-1820
  • Monika Prendecka Department of Biochemistry, Maria Curie-Skłodowska University Author

DOI:

https://doi.org/10.12923/

Keywords:

CNS-stimulating mushrooms, 5HT receptors agonist, 5HT receptor antagonist, Clitocybe sp., Tricholoma sp.

Abstract

Novel CNS-stimulating activities were extracted from the fruit bodies of mushrooms from genus Clitocybe and Tricholoma. Fractions active against 5HT5A and 5HT2C receptors, and NET transporters were extracted with methanol, ethanol, cold water and hot water. Their 5HT receptors agonism and antagonism  potency were characterized against appropriate receptor proteins. It indicates that the fungi from genus Clitocybe and Tricholoma can be treated as new “magic mushrooms” with CNS-stimulating activities. And these organics are very promising bioactive substances. It means that these mushrooms are a very promising source for potential therapeutic and psychotropic purposes, also.

References

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Published

2025-04-09

Issue

Vol. 23 No. 2 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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