Preventive action of maleimide derivative 1-(4-Cl-benzil)-3-Cl-4-(CF3-fenilamino)-1Н-pyrrol-2,5-dion on rat’s renal system in 1,2-dimethylhydrasine-induced colon carcinogenesis

Authors

  • Iryna Kharchuk Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author
  • Olena Filinska Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author
  • Svitlana Yablonska Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author
  • Volodymyr Rybalchenko Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author

DOI:

https://doi.org/10.12923/

Keywords:

maleimide derivative, 1,2-dimethylhydrasine, renal system, colon carcinogenesis

Abstract

The novel maleimide derivative 1-(4-Cl-benzil)-3-Cl-4-(CF3-fenilamino)-1Н-pirol-2,5-dion does not cause significant structure-functional changes in rats’ kidneys after 20 weeks’ daily administration. The induction of proliferate activity of distal tubules epithelial cells and reduction of proximal tubules epithelial layer thickness in kidneys of rats with colon tumors in 1,2-dimethylhydrazine-induced colon carcinogenesis were observed. Maleimide derivative displays some preventive action to tubular apparatus of rats’ kidney cortical nephrons and reduces the frequency of preneoplastic changes in tubules epithelial cells in experimental colon carcinogenesis conditions.

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Published

2025-04-09

Issue

Vol. 23 No. 2 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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