Effect of manganese, cadmium, plumbum and mercury ions on the expression of SNF1/AMP-activated protein kinase in the rat liver, lungs, kidney and heart
DOI:
https://doi.org/10.12923/Keywords:
SNF1/AMP-activated protein kinase (SNARK), manganese, cadmium, plumbum, mercury, ratsAbstract
The expression of SNF1/AMP-activated protein kinase (SNARK) mRNA was significantly decreased in the lung, heart and kidney in rats treated with manganese. Significant induction of protein kinase SNARK mRNA expression was observed in the liver and lungs in rats treated with plumbum and mercury, but cadmium enhances this mRNA expression in the liver only. At the same time the expression of kinase SNARK mRNA in the heart is decreased in animals treated with manganese, plumbum and mercury salts. Thus, results of this investigation demonstrated that cadmium, manganese, plumbum and mercury can affect some important regulatory mechanisms which control cell metabolism at the SNARK protein kinase level.
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