PI3-kinase signaling pathway mediates changes in the structural and functional state of leukocyte membranes under type 1 diabetes mellitus

Authors

  • Mykola Zdioruk Ivan Franko Lviv National University, Biochemistry Department Author
  • Iryna Brodyak Ivan Franko Lviv National University, Biochemistry Department Author
  • Viktor Drel Ivan Franko Lviv National University, Biochemistry Department Author
  • Nataliya Sybirna Ivan Franko Lviv National University, Biochemistry Department Author

DOI:

https://doi.org/10.12923/

Keywords:

type 1 diabetes mellitus, leukocyte, aggregation activity, lectins

Abstract

The research reveals the lectin-induced leukocyte aggregation abilities in healthy donors and type 1 diabetics. It is shown that PI-3’-kinase participates in signal pathways mediating changes in molecular mechanisms responsible for aggregation and adhesion of leukocytic series blood cells. The obtained results may be used in the development of a test system for diabetic diagnosis.

References

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3. Nurun Nabi A.H.M., Islam L.N. et al.: Polymorphonuclear Neutrophil Dysfunctions in Streptozotocin-induced Type 1 Diabetic Rats. J. Biochem. Mol. Biol., 38, 661, 2005.

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6. Sybirna N.О., Barska М.L.: Funktsional’ny stan neitrofiliv pry tsukrovomu diabeti 1 typu Laboratorna Diahnostyka, 2, 33, 2003.

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Published

2025-04-09

Issue

Vol. 23 No. 2 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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