Influence of melanin on the lesion in the gastric mucosa of rats caused by neuro-muscular tension according to Selye

Authors

  • YA. Savytskyy Danylo Halytskyi Lviv National Medical University Author
  • D. Golyshkin Taras Shevchenko National University of Kyiv, Ukraine Author
  • T. Falalyeyeva Taras Shevchenko National University of Kyiv, Ukraine Author

DOI:

https://doi.org/10.12923/

Keywords:

melanin, stress, gastric mucosa

Abstract

In acute experiments on 30 white rats it was established that melanin decreased the area of ulcers in gastric mucosa evoked by stress according to Selye. But the decrease of length of erosions was statistically unreliable. Reduction of gastric lesions was accompanied by normalization of the content of lipid peroxidation products in gastric mucosa. Melanin increased the activity of superoxide dismutase and decreased the activity of catalase compared with the activity of these enzymes in the group of rats susceptible to stress. The obtained data allow to consider melanin as a promising means of prophylaxis against stress lesions of the gastric mucosa.

References

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Published

2025-04-09

Issue

Vol. 23 No. 2 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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