Impact of cyclooxygenase inhibitors on proteolysis of fibronectin and activity of gelatinases in experimental cardiomyopathy
DOI:
https://doi.org/10.12923/Keywords:
gelatinases A and B, fibronectin, doxorubicin, cardiomiopathy, COX-1, COX-2Abstract
The activity of gelatinases A and B, fibronectin concentration and its fragmentation in plasma of rats with doxorubicin-induced cardiomyopathy were investigated. It was shown that the treatment with COX-1 inhibitors leads to a significant decrease of MMP-9 and proMMP2 activities, and treatment with celecoxib (COX-2 inhibitor) leads to an increase of both forms of MMP-2. Fibronectin degradation was increased in animals treated with COX inhibitors.
References
1. Kandasamy A. et al.: Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix. Cardiovascular Research, 85, 413, 2010.
2. Каlinkina N.V.: Аntratsiklinovaya kardiomiopatiya. DonGIII, 236, 2001.
3. Troeberg L. et al.: Zymography of metalloproteinases. Current Protocols in Protein Science, 21.15, 2003.
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