Amikacin-modified hybrid biomaterial biological properties

Authors

DOI:

https://doi.org/10.12923/

Keywords:

hydroxyapatite, amikacin, antibiotic immobilization, implant infection, cytotoxicity

Abstract

Hydroxyapatite is used in bone reconstruction because of its similar chemical structure compared to the inorganic composition of human bone. Bone is a complex material composed of proteins, mainly collagen, with hydroxyapatite. Therefore, now many investigations are focused on the hybrid biomaterials of hydroxyapatite with proteins and other synthetic polymers. We investigated HAp granules covered by two types of proteins (keratin or gelatin) in our study. This biomaterial was also modified by amikacin. In our previous paper (12) we proved that such hybrid biomaterial had antimicrobial properties. This paper gives evidence that HAp-modified granules did not influence on growth and proliferation of osteoblasts. So this new biomaterial could be used as an implant on orthopaedic, oral and maxillo-facial surgery in the future.

References

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Published

2010-09-30

Issue

Vol. 23 No. 3 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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