Non-invasive markers of hepatic encephalopathy under chronic hepatitis C and2-oxoglutarate treatment

Authors

  • Galyna Ushakova Dniepropetrovsk National University named by Oles` Gonchar, Department of Biophysics and Biochemistry, Ukraine Author
  • Olga Fomenko Dniepropetrovsk National University named by Oles` Gonchar, Department of Biophysics and Biochemistry, Ukraine Author
  • Stefan Pierzynowski Lund University, Department of Cell and Organism Biology, Sweden Author

DOI:

https://doi.org/10.12923/

Keywords:

chronic hepatitis C, encephalopathy, S-100b, 2-oxoglutarate

Abstract

The level of the non-invasive markers of hepatic fibrosis and astroglia damage under chronic hepatitis C (CHC) and 2-oxoglutarate treatment was investigated. The obtained data allow for the suggestion that S-100b level in the blood serum may be used as a marker of hepatic encephalopathy under CHC, the treatment with 2-oxoglutarate can prevent serious brain damage caused by ammonia effect.

References

1. Bajaj J.S.: Minimal hepatic encephalopathy matters in daily life. World J. Gastroenterol., 14, 3609, 2008.

2. Bongiovanni M, Casana M.: Non-invasive markers of liver fibrosis in HCV mono-infected and in HIV/HCV co-infected subjects. Med. Chem., 4, 513, 2008.

3. Bradford M.M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248, 1976.

4. Butterworth R.F.: Pathophysiology of hepatic encephalopathy: A new look at ammonia. Metab. Brain Dis., 17, 221, 2002.

5. Gold E.W.: The quantitative spectrophotometric estimation of total sulfated glycosaminoglycan levels. Formation of soluble alcian blue complexes. Biochim. Biophys. Acta, 673, 408, 1981.

6. Lai J.C., Cooper A.J.: Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors. J. Neurochem., 47, 1376, 1986.

7. Nikolenko V.Y., Nikolenko Y.I., Nikolenko O.Y.: Pat. 15752 Ukraine, MPK G 09 B 23/28. Chronic hepatitis C development; Doneck State Medical University, № u2006004614.

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Published

2010-09-30

Issue

Vol. 23 No. 3 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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Copyright (c) 2010 Authors

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