Hypoglycemic and antioxidant action of melatonin in alloxan diabetic rats

Authors

  • Ivan Meshchyshen Bukovinian State Medical University, Chernovic, Ukraine Author
  • Olexandra Kushnir Bukovinian State Medical University, Chernovic, Ukraine Author
  • Iryna Yaremii Bukovinian State Medical University, Chernovic, Ukraine Author

DOI:

https://doi.org/10.12923/

Keywords:

melatonin, alloxan diabetes, carbohydrate metabolism, antioxidant protection, liver, rats

Abstract

This study investigated the possible protective effects of melatonin as an antioxidant against alloxan-induced diabetic liver injury in rats. The introduction of melatonin to alloxan diabetic rats is conducive to a decrease in them of the level of basal glycemia BG and HbA1c, as well as stabilization of the indices of the body’s antioxidant defense disturbed, namely total antioxidant activity (TAOA) of blood plasma, malonic dialdehyde (MDA) and glutathione (G-SH) in rats liver.

References

1. Brömme H.J. et al.: Influence of oxygen concentration on redox cycling of alloxan and dialuric acid. Horm. Metab. Res., 37, 729, 2005.

2. Derlacz R.A. et al.: Melatonin is more effective than taurine and 5-hydroxytryptophan against hyperglycemia-induced kidney-cortex tubules injury. J. Pineal. Res., 42, 203, 2007.

3. Ghareeb D. A. et al.: Vanadium improves brain acetylcholinesterase activity on early stage alloxan-diabetic rats. Neurosci. Lett., 436, 44, 2008.

4. Gumieniczek A. et al.: Nitrosative stress and glutathione redox system in four different tissues of alloxan-induced hyperglycemic animals. Toxicol. Mech. Methods., 19, 302, 2009.

5. Shieh J. M. et al.: Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCzeta-Akt-GSK3beta pathway in hepatic cells. J. Pineal. Res., 47, 339, 2009.

6. Song F.: Oxidative stress, antioxidant status and DNA damage in patients with impaired glucose regulation and newly diagnosed Type 2 diabetes. Clin. Sci. (Lond)., 112, 599, 2007.

7. Xu N. et al.: Suppression of apolipoprotein M expression and secretion in alloxan-diabetic mouse: Partial reversal by insulin. Biochem. Biophys. Res. Commun., 342, 1174, 2006.

Downloads

Published

2010-09-30

Issue

Vol. 23 No. 3 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

License

Copyright (c) 2010 Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.