Synthesis and antitumor activity evaluation of new 2-(4-alkоxyphenylamino)thiazol-4(5H)-оnes derivatives

Authors

  • Ivanna Subtel’na Danylo Halytskyi Lviv, Department of Pharmaceutical, Organic and Bioorganic Chemistry, National Medical University, Ukraine Author
  • Borys Zimenkovsky Danylo Halytskyi Lviv, Department of Pharmaceutical, Organic and Bioorganic Chemistry, National Medical University, Ukraine Author
  • Roman Lesyk Danylo Halytskyi Lviv, Department of Pharmaceutical, Organic and Bioorganic Chemistry, National Medical University, Ukraine Author

DOI:

https://doi.org/10.12923/

Keywords:

2-arylaminothiazol-4(5H)-ones, [2+3]-cyclocondensation, Knoevenagel reaction, antitumor activity

Abstract

5-Substituted 2-(4-alkoxyphenylamino)thiazol-4(5H)-ones were synthesized. Anticancer activity of synthesized compounds toward 60 human tumor cell lines panel in National Cancer Institute was evaluated. 4-Ethoxycarbonylphenylamide of 5-carboxymethyl-2-(4-methoxyphenylamino)thiazol-4(5H)-one was selected as lead-compound with high antitumor activity.

References

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Published

2010-09-30

Issue

Vol. 23 No. 3 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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