Serological markers of cognitive deficit development in the acute period of traumatic brain injury

Authors

  • Olha Kukhlenko Danylo Halytskyi Lviv National Medical University, Department of Neurology and Neurosurgery, Faculty of Postgraduate Education, Ukraine Author

DOI:

https://doi.org/10.12923/

Keywords:

traumatic brain injury, cognitive deficit, nitric oxide, superoxide dismutase

Abstract

The aim of our work was to investigate the state of cognitive functions in patients in acute period of mild and moderate traumatic brain injury according to the standard tests of neuropsychological diagnostics and to evaluate the sensitivity of assay of lipid peroxidation activity, SOD and catalase activities and NO-metabolites concentration as serological tests for the routine diagnostics of early posttraumatic cognitive deficit. The combination of neuropsychological testing with scale FAB and laboratory determination of NO2- and SOD activity can be a useful diagnostic tool for posttraumatic patients who require extra attention from neuropsychologists for more adequate treatment in the acute period of craniocerebral trauma. The choice of the mentioned markers is pathogenically substantiated and can be used in routine clinical practice for the precise diagnostics of posttraumatic cognitive deficit.

References

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Published

2010-09-30

Issue

Vol. 23 No. 3 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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Copyright (c) 2010 Authors

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