Peculiarities of the combined influence of hypothyroidism and ionizing radiation on the oxygen-dependent metabolism in hepatic tissues

Authors

  • Oksana Melnyk Danylo Halytsky Lviv National Medical University, Normal Physiology Department, Ukraine Author
  • Mechyslav Gzhegotskyi Danylo Halytsky Lviv National Medical University, Normal Physiology Department, Ukraine Author
  • Oksana Terletska Danylo Halytsky Lviv National Medical University, Normal Physiology Department, Ukraine Author
  • Svitlana Kovalchuk Danylo Halytsky Lviv National Medical University, Normal Physiology Department, Ukraine Author
  • Olesya Chupashko Danylo Halytsky Lviv National Medical University, Normal Physiology Department, Ukraine Author
  • Oksana Chupashko Danylo Halytsky Lviv National Medical University, Normal Physiology Department, Ukraine Author

Keywords:

hypothyroidism, small doses of ionizing irradiation, hepatic tissues, lipoperoxidation, antioxidant activity, single action, combined action

Abstract

The search for the preclinical criteria of the derangements of adaptative reactions among the metabolic changes caused by free-radical peroxidation is substantiated. With that purpose, the research on the peculiarities of lipoperoxidation and antioxidant activity in hepatic tissues of male rats under the conditions of single and combined action of hypothyroidism and small doses of radiation was produced. The results of the joint influence of extreme factors demonstrate a decrease in activation of lipoperoxidation in hepatic tissues. At the same time, the general antioxidant activity, activities of glutathione peroxidase and superoxid dismutase were progressively decreasing. Such character of these processes signifies the diminution of the adaptative ability of the compensatory reactions.

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Published

2010-12-30

Issue

Vol. 23 No. 4 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

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Artykuły

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