Effect of substances obtained from grape seed on nitrogen oxide system under experimental diabetes

Authors

  • Andriy Zagayko Biochemistry Department, National University of Pharmacy, Ukraine Author
  • Larysa Voronina Biochemistry Department, National University of Pharmacy, Ukraine Author
  • Anna Kravchenko Biochemistry Department, National University of Pharmacy, Ukraine Author
  • Oksana Krasilnikova Biochemistry Department, National University of Pharmacy, Ukraine Author

Keywords:

diabetes, arginine, citrulline, arginase, grape seed

Abstract

The aim of the present research was to study influence polyphenolic concentrates “Merlo”, “Rkacitelli” on NO-synthase system at control animals and animals with experimental DM1 and DM2.

It has been shown that the increase of arginine content in blood serum, which we observed in our experiment, was accompanied by decrease of NO. This effect can be caused by  decrease of enzyme affinity to substrate and also by decrease of arginine transport into cells taking place under DM1. The normalization of the NO, arginine and citrulline levels in rats blood serum after polyphenol concentrates administration apparently and most likely depends on their high antioxidant activity.

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Published

2010-12-30

Issue

Vol. 23 No. 4 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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