Pttg-1 knockout gene leads to structural and functional changes in peripheral blood cells in mice

Authors

  • Olena Kanyuka Ivan Franko Lviv National University, Biochemistry Department, Institute of Cell Biology, Ukraine Author
  • Sergey Afanasyev Ivan Franko Lviv National University, Biochemistry Department, Institute of Cell Biology, Ukraine Author
  • Yevhen Filyak Ivan Franko Lviv National University, Biochemistry Department, Institute of Cell Biology, Ukraine Author
  • Oksana Filyak Ivan Franko Lviv National University, Biochemistry Department, Institute of Cell Biology, Ukraine Author
  • Rostyslav Stoika Ivan Franko Lviv National University, Biochemistry Department, Institute of Cell Biology, Ukraine Author
  • Natalia Sybirna Ivan Franko Lviv National University, Biochemistry Department, Institute of Cell Biology, Ukraine Author

Keywords:

pituitary tumor transforming gene-1, Pttg-1, gene knockout, mouse, blood cells

Abstract

Pituitary tumor transforming gene-1 is involved in the regulation of mitotic sister chromatid separation. We studied the effect of pttg-KO upon the production of new blood cells and elimination of erythrocytes. It can be concluded that pttg-1 might play an important role in the regulation of haemopoesis.

References

1. Gabbasov Z.A., Popov E.G., Gavrilov I.Yu., Posin E.Ya.: Platelet aggregation: the use of optical density fluctuations to study microaggregate formation in platelet suspension. Thromb. Res., 54, 215, 1989.

2. Stoika R., Melmed S.: Expression and function of pituitary tumour transforming gene for T-lymphocyte activation. Br. J. Haematol., 119, 1070, 2002.

3. Wang Z., Yu R., Melmed S.: Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Mol. Endocrinol., 15, 1870, 2001.

4. Zou H., MaGarry T. J., Bernal T., Kirschner M. W.: Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis. Science 285, 418, 1999.

Downloads

Published

2010-12-30

Issue

Vol. 23 No. 4 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

License

Copyright (c) 2025 Olena Kanyuka, Sergey Afanasyev, Yevhen Filyak, Oksana Filyak, Rostyslav Stoika, Natalia Sybirna (Autor)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.