Influence of  the type of the dissolution medium on the UV spectra of diclofenac sodium

Regina Kasperek; Katarzyna Świąder; Maria Zuń; Piotr Belniak; Łukasz Zimmer; Ewelina Dobiecka; Ewa Poleszak

Authors

Regina Kasperek Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland Author https://orcid.org/0000-0001-7676-8620
Katarzyna Świąder Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland Author https://orcid.org/0000-0002-9214-927X
Maria Zuń Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland Author https://orcid.org/0000-0003-2539-8935
Piotr Belniak Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland Author https://orcid.org/0000-0002-1036-1884
Łukasz Zimmer Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland Author https://orcid.org/0000-0003-2315-2747
Ewelina Dobiecka Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland Author
Ewa Poleszak Chair and Department of Applied Pharmacy, Medical University of Lublin, Poland Author https://orcid.org/0000-0003-4359-3953

Keywords:

diclofenac sodium, dissolution media, absorbance, UV spectra

Abstract

The UV spectra of diclofenac sodium at concentration 10 µg/ml in nineteen dissolution media were obtained. According to the absorptivity values and shift of wavelengths at maximum and minimum absorbances, four of the dissolution media were chosen for the studies. Stability of phosphoric buffer at pH 6.8 and citric buffer at pH 6.5 was maintained to 8 h and 11 h, respectively. These dissolution media can be used for the release studies of diclofenac sodium from the pharmaceutical preparations.

References

1. Martindale: The complete drug reference. The Pharmaceutical Press, London, 2011.

2. Pharmindex 2011. Vademecum of Drugs. UBM Medica Poland.

3. Chiarini A., Tartarini A., Fini A.: pH-solubility relationship and partition coefficients for some anti-inflammatory arylaliphatic acids. Arch. Pharm., 317, 268, 1984.

4. O’Connor K., Corrigan O.: Preparation and characterization of a range of diclofenac salts. Int. J. Pharm., 226, 163, 2001.

5. Palomo M., Ballesteros M., Frutos P.: Analysis of diclofenac sodium derivatives. J. Pharm. Anal., 21, 83, 1999.

6. Proikakis C., Tarantili P., Andreopoulos A.: The role of polymer/drug interactions on the sustained release from poly(DL-lactic acid) tablets. Eur. Polym. J. 42, 3269, 2006.

7. Fele Zilnik L., Jazbinsek A., Hvala A. et al.: Solubility of sodium diclofenac in different solvents. Fluid Phase Equilibria, 261, 140, 2007.

8. Kincl M., Meleh M., Veber M. et al.: Study of physicochemical parameters affecting the release of diclofenac sodium from lipophilic matrix tablets. Acta Chim. Slov., 51, 409, 2004.

9. Marzec A.: The studies of biological availability and bioavailability. Centre of scientific information Oinpharma, Warsaw, 2007.

10. The United States Pharmacopoeia USP XXII, Washington, 1990.

11. Polish Pharmacopoeia VIII, Warsaw, 2008.

12. Guseva S., Karlina M., Pozharitskaya O. et al.: Validation of a quantitative determination method of diclofenac for in vitro bioequivalence evaluation of transdermal gel preparations. Pharm. Chem. J., 44, 1, 43, 2010.

13. Kocjan R.: Analytical chemistry – Instrumental analysis. PZWL, Warsaw, 2000.

Influence of the type of the dissolution medium on the UV spectra of diclofenac sodium

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