Oxidative coupling reactions: a visual method for determining anthranilic acid derivatives
DOI:
https://doi.org/10.12923/cipms-2026-0015Keywords:
anthranilic acid derivative, anthranilic hydrazide, potassium periodate, oxidative couplingAbstract
The anthranilic acid derivative, anthranilic hydrazide, is a very important compound in medicine, although it was recently developed to reduce the side effects of anthranilic acid. Since anthranilic acid derivative hydrazide is a newly produced product, there are few methods for estimating this significant component. Consequently, a simple, inexpensive, and rapid spectrophotometric approach has been developed to determine this chemical in various samples. The two-step method consists of oxidizing the compound with potassium periodate in an acidic medium. A red compound gradually forms after coupling with the 2-amino-4-chloro phenol reagent. Then, the concentration of the compound steadily increases in the second step. The method followed Beer's law at concentrations ranging from 1 to 32.5 µg/mL with a Sandall's value of 0.0245 µg-2 cm-1 and a molar absorptivity of of 0.899×10⁴ L mol-1 cm-1. This method was successful in determining the amount of anthranilic acid derivative hydrazide in several samples.
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Copyright (c) 2026 Fatimah Nazar Mahmood, Farah Younis Hamid, Thaira Idress Younis, Shayma M. Nayif, Hyffaa Y. Hussien (Autor)
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