Vol. 27 No. 4 (2014), Artykuły
Vol. 27 No. 4 (2014)

Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

Artykuły
Published 2015-03-03
Oleg Gerush
Bukovinian State Medical University, Department of Pharmacy, Department of Bio-organic and Biological Chemistry and Clinical Biochemistry, 2 Teatralna Sq., Chernivtsi, Ukraine
Olena Lenytska
National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine
Larysa Yakovleva
National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine
Liudmyla Gladkova
National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine
Igor Gerush
Bukovinian State Medical University, Department of Pharmacy, Department of Bio-organic and Biological Chemistry and Clinical Biochemistry, 2 Teatralna Sq., Chernivtsi, Ukraine
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Keywords

liver
hepatitis
hepatoprotective action
“Phytovenol” capsules

Abstract

This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector - “Silibor” tablets. The results obtained suggest that it is possible to extend the range of available hepatoprotectors and improve the quality of treatment for liver diseases, by introducing “Phytovenol” capsules into medical practice.

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