Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

Authors

  • Oleg Gerush Bukovinian State Medical University, Department of Pharmacy, Department of Bio-organic and Biological Chemistry and Clinical Biochemistry, 2 Teatralna Sq., Chernivtsi, Ukraine Author
  • Olena Lenytska National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine Author
  • Larysa Yakovleva National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine Author
  • Liudmyla Gladkova National Pharmaceutical University, Department of Pharmacoeconomics, Central Scientific-Research Laboratory, Kharkiv, Ukraine Author
  • Igor Gerush Bukovinian State Medical University, Department of Pharmacy, Department of Bio-organic and Biological Chemistry and Clinical Biochemistry, 2 Teatralna Sq., Chernivtsi, Ukraine Author

DOI:

https://doi.org/10.1515/cipms-2015-0024

Keywords:

liver, hepatitis, hepatoprotective action, “Phytovenol” capsules

Abstract

This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector - “Silibor” tablets. The results obtained suggest that it is possible to extend the range of available hepatoprotectors and improve the quality of treatment for liver diseases, by introducing “Phytovenol” capsules into medical practice.

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Published

2015-03-03

Issue

Vol. 27 No. 4 (2014): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

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