Disorders of purines and pyrimidines metabolism in human gastrointestinal tract cancer

Authors

  • Berta Borzenko M. Gorky Donetsk National Medical University, Department of Chemistry, Ukraine Author
  • Elena Bakurova M. Gorky Donetsk National Medical University, Department of Chemistry, Ukraine Author
  • Ksenia Mironova M. Gorky Donetsk National Medical University, Department of Chemistry, Ukraine Author

DOI:

https://doi.org/10.12923/j.2084-980X/26.4/a.02

Keywords:

cancer, thymidine phosphorylase, thymidine kinase, 5′-nucleotidase of AMP, adenosine deaminase, blood serum, lymphocytes

Abstract

Patients with cancer of stomach, colon cancer and rectum showed an increase in the thymidine kinase, 5'–nucleotidase of adenylate, adenosine deaminase activities and a decrease in the thymidine phosphorylase activity, which can cause DNA biosynthesis and increase of proliferation. The lymphocyte 5'–nucleotidase of adenylate, adenosine deaminase activities are associated with cellular dysfunction and can be used as a biochemical tests of it.

References

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Published

2013-12-30

Issue

Vol. 26 No. 4 (2013): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

License

Copyright (c) 2013 Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

How to Cite

Borzenko, B., Bakurova, E., & Mironova, K. (2013). Disorders of purines and pyrimidines metabolism in human gastrointestinal tract cancer. Current Issues in Pharmacy and Medical Sciences, 26(4), 369-371. https://doi.org/10.12923/j.2084-980X/26.4/a.02