Sialylation status of leukocyte cell-surface glycoconjugates in streptozotocin-induced diabetic rats and after treatment with agmatine

Authors

  • Iryna Ferents Ivan Franko National University of Lviv, Department of Biochemistry of Biology Faculty, Ukraine Author
  • Iryna Brodyak Ivan Franko National University of Lviv, Department of Biochemistry of Biology Faculty, Ukraine Author
  • Maryana Lyuta Ivan Franko National University of Lviv, Department of Biochemistry of Biology Faculty, Ukraine Author
  • Natalia Klymyshyn Ivan Franko National University of Lviv, Department of Biochemistry of Biology Faculty, Ukraine Author
  • Volodymyra Burda Ivan Franko National University of Lviv, Department of Biochemistry of Biology Faculty, Ukraine Author
  • Natalia Sybirna Ivan Franko National University of Lviv, Department of Biochemistry of Biology Faculty, Ukraine Author

DOI:

https://doi.org/10.12923/j.2084-980X/26.4/a.08

Keywords:

experimental diabetes mellitus, leukocyte, membrane glycoconjugates, sialic acid, agmatine

Abstract

Development of experimental diabetes mellitus in rats was accompanied by increase of desialylation of carbohydrate determinants of leukocyte membrane glycoproteins. A decreased level of both α (2,3)- and α(2,6)-linked sialic acid residues and uncovering the penultimate galactose residues was shown. Our findings shown increase in sialation (in particular α(2,3) sialation) of oligosaccharide sequences of leukocytes membrane glycoconjugates after treatment diabetic rats with agmatine. Detected changes in configuration of leukocyte membrane components in diabetic animals after agmatine administration indicate the positively effects of this polyamine due to its hypoglycemic effect.

References

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Published

2013-12-30

Issue

Vol. 26 No. 4 (2013): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

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Copyright (c) 2013 Authors

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

How to Cite

Ferents, I., Brodyak, I., Lyuta, M., Klymyshyn, N., Burda, V., & Sybirna, N. (2013). Sialylation status of leukocyte cell-surface glycoconjugates in streptozotocin-induced diabetic rats and after treatment with agmatine. Current Issues in Pharmacy and Medical Sciences, 26(4), 390-392. https://doi.org/10.12923/j.2084-980X/26.4/a.08