The inhibition of rat leukocytes apoptosis under the condition of experimental diabetes mellitus type 1 by Galega officinalis L.

Authors

  • Mariia Khokhla Ivan Franko National University of Lviv, Biochemistry Department, Ukraine Author
  • Galyna Kleveta Ivan Franko National University of Lviv, Biochemistry Department, Ukraine Author
  • Marjana Lupak Ivan Franko National University of Lviv, Biochemistry Department, Ukraine Author
  • Mariia Skybitska Ivan Franko National University of Lviv, Biochemistry Department, Ukraine Author
  • Yaroslav Chajka Ivan Franko National University of Lviv, Biochemistry Department, Ukraine Author
  • Natalia Sybirna Ivan Franko National University of Lviv, Biochemistry Department, Ukraine Author

DOI:

https://doi.org/10.12923/j.2084-980X/26.4/a.09

Keywords:

Galega officinalis L., diabetes mellitus, leukocytes, apoptosis, sialic acid

Abstract

The article contains the data of Galega officinalis extract (GOE) nonalkaloid-containing fraction influence on the structural and functional state of leukocytes under the condition of experimental diabetes mellitus type 1 (EDM). Immunohistochemical method has shown the quantitative redistribution of leukocytes containing proapoptotic protein p53 and PARylated [poly(ADP-ribosyl) ated] proteins under EDM conditions and admission of the tested extract. GOE administration to animals with EDM leads to the reduction in the number of cells with positive and strongly positive reaction to the p53 protein and PARylated proteins content, indicating its depressing effect on apoptosis of immune cells.

References

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Published

2013-12-30

Issue

Vol. 26 No. 4 (2013): Current Issues of Pharmacy and Medical Sciences

Section

Artykuły

License

Copyright (c) 2013 Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.

How to Cite

Khokhla, M., Kleveta, G., Lupak, M., Skybitska, M., Chajka, Y., & Sybirna, N. (2013). The inhibition of rat leukocytes apoptosis under the condition of experimental diabetes mellitus type 1 by Galega officinalis L. Current Issues in Pharmacy and Medical Sciences, 26(4), 393-397. https://doi.org/10.12923/j.2084-980X/26.4/a.09