Meclophenoxate ion-selective plastic membrane sensors and their pharmaceutical applications
DOI:
https://doi.org/10.12923/j.2084-980X/25.1/a.01Keywords:
anti-aging drugs, meclophenoxate, monitoring, membrane electrodesAbstract
The present work describes the construction and general characteristics of meclophenoxate ion-selective plastic membrane sensors, based on the use of a meclophenoxate–tetrakis(4-chlorophenyl)borate ion-pair complex as electroactive material, with 1-isopropyl-4-nitrobenzene (electrode A), 2-nitrophenyloctyl ether (electrode B), 2-nitrodiphenyl ether (electrode C) or bis(2-ethylhexyl) sebacate (electrode D) as solvent mediators. The electrodes show a linear response to the meclophenoxate concentration ranges of 10-4,1 – 10–2 moll-1 (electrode A), 10-5,1 – 10–2 moll-1 (electrode B), 10-4 – 10–2 moll-1 (electrode C), 10-4,9 – 10–2 moll-1 (electrode D), over the pH range of 4.12 – 6.18 with a cationic slope of 61.7; 64.7; 63,33; 64,41 mV decade-1, respectively. The response time varied from 5 to 20s, depending on the meclophenoxate concentration. Electrode B was used for the potentiometric determination of the content of meclophenoxate hydrochloride in pure form, dragees and dragee dissolution test, with average recovery and mean standard deviation (±SD) of 101.79 1.57, 102.72 0.91 and 101.32 ± 0.84 of nominal values respectively.
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