The anti-HIV, anti-tumor activity of allyl derivatives of 1,2,4-triazole-5-thione, 1,3,4-thiadiazol-2-ylamine and derivatives of bicyclic systems: 1,2,4-triazole[3,4-b]1,3-thiazine, 1,2,4-triazole[3,2-b]1,3-thiazine, thiazolo[2,3-c][1,2,4]triazole
DOI:
https://doi.org/10.12923/j.2084-980X/25.1/a.22Keywords:
1,2,4-Triazole[3,4-b]1,3-thiazine, 1,2,4-triazole[3,2-b]1,3-thiazine, thiazolo[2,3-c][1,2,4]triazole, 1,2,4-triazole-5-thione, 1,3,4-thiadiazole, the anti-HIV, in vitro and atitumor activity, in vivoAbstract
The isomerization of 5H-3,7-diphenyl 6,7-dihydro-1,2,4-triazole[3,4-b] 1,3-thiazine (1) in a sealed tube, in the presence of aqueous Hbr, was carried out, and 7H-2,5-diphenyl-5,6-dihydro 1,2,4-triazole[3,2-b]1,3-thiazine (2) was obtained. The 7H-2,5-diphenyl 5,6-dihydro-1,2,4-triazole[3,2-b]1,3-thiazine (2), 5H-3-phenylmethyl-7-phenyl-6,7-dihydro-1,2,4-triazole[3,4-b]1,3-thiazine (3), the 3-phenylmethyl-6-methyl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazole (4), 3-(o-hydroxy-phenyl-)6-methyl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazole (5) were evaluated against HIV-1. The anti-tumor activities of 3-(pyridin-2-yl)-4-allyl-1,2,4-triazole-5-thione (6), 2N-cinnamyl-5-methyl-[1,3,4]thiadiazol-2-yl amine (7), 7H-2,5-diphenyl 5,6-dihydro-1,2,4-triazole[3,2-b]1,3-thiazine (2), 5H-3-phenylmethyl-7-phenyl-6,7-dihydro-1,2,4-triazole[3,4-b]1,3-thiazine (3), the 3-phenylmethyl-6-methyl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazole (4), 3-(o-hydroxy-phenyl-)6-methyl-5,6-dihydrothiazolo[2,3-c][1,2,4]triazole (5) were tested against the IP P388 Leukemia 3PS31.
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