The effect of prolonged incubation time on the interaction between PAMAM dendrimers and iminodiacetic acid derivatives
DOI:
https://doi.org/10.12923/j.2084-980X/25.4/a.12Keywords:
PAMAM dendrimers, solubility studies, iminodiacetic acid, electrostatic interactionsAbstract
Dendrimers, highly branched spherical polymers, are known for their ability to act as solubility enhancers of various types of drugs. In the present study, we investigated the potential of poly(amidoamine) (PAMAM) dendrimers G1-G4 in concentration from 0 to 10 mg/mL for solubility of two iminodiacetic acid derivatives after prolonged (72 hour) incubation time. The experiments were conducted by means of the equilibrium solubility method which is based on the spectrophotometric measurements of compounds’ absorbance solubilized in the presence of PAMAM dendrimers. We reported that PAMAM dendrimers contribute to significant solubility enhancement of tested compounds. This effect is concentration- and generation- dependent. The results of solubility studies after 72 h incubation time suggest that the interactions between iminodiacetic acid derivatives and PAMAM dendrimers, mainly electrostatic and hydrophobic, are stable in aqueous environment.
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