The effect of COX-2 inhibitor celecoxib and proton pump blockerlansoprazole on lipoperoxidation processes in heart tissueand gastric mucosa of streptozotocin-induced diabetic in rats

Authors

  • Iryna Fomenko Danylo Halytsky Lviv National Medical University Author
  • Tetyana Bondarchuk Danylo Halytsky Lviv National Medical University Author
  • Olexandr Sklyarov Danylo Halytsky Lviv National Medical University Author
  • Katarzyna Swierzko Medical University of Lublin Author
  • Janusz Solski Medical University of Lublin Author

Abstract

The influence of COX-2 inhibitor celecoxib and proton pump blocker lansoprazole on lipoperoxidation, antioxidation defense and the content of nitrogen oxide in rats’ gastric mucosa and heart tissue with streptosotocin diabetes was studied. The obtained results showed that lipoperoxidation processes were activated in diabetic animals and the activity of antioxidation protection enzymes increased. Inhibition of prostaglandins synthesis by COX-2 decreased oxidative stress in both investigated tissues. Proton pump blockage led to a sharp increase of NO content in heart tissue and a decrease of MDA content in gastric mucosa.

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Volume XXII, 3

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Published

2009-09-30

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Vol. 22 No. 3 (2009): Annales UMCS, Pharmacia, Sectio DDD, Volume XXII

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