Influence of topiramate and its combination with valproate on the locomotor activity in mice
Keywords:
exploratory and spontaneous locomotor activities, valproate, topiramate, ambulatory and rearing activities, total distance, adverse-effect profile, miceAbstract
The aim of this study was to determining the effect of topiramate (TPM - a newer antiepileptic drug) co-administered with valproate (VPA) on the exploratory and spontaneous activities in mice. Locomotor activity was monitored electronically using a Digiscan system with relation to the ambulatory and rearing activities, as well as total distance traveled by animals within two 15-min. periods. Results indicated that TPM (5 mg/kg) and VPA (203 mg/kg) administered alone did not alter the exploratory and spontaneous locomotor activities with respect to all parameters studied in mice. Similarly, the drug combination of VPA (203 mg/kg) with TPM (5 mg/kg) also did not influence either spontaneous or exploratory locomotor activities in animals. As the combination of TPM with VPA unchanged locomotion in experimental animals, it seems that clinical application of these drugs in combination is favorable.
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