Renal function and anemia status determination at the early stages of kidney transplant function
Keywords:
kidney transplantation, renal function, chronic renal failureAbstract
Introduction. Along with the world tendency of increased number of patients with chronic kidney diseases, the number of individuals undergoing renal replacement therapy also augments. From all methods of such kind of therapy, renal transplantation is considered to be most optimal. The aim of this study was to assess the renal function during a 26-week follow-up post-transplantation period.
Methods. Measurements were carried out on 25 patients with chronic end-stage renal failure qualified for allogenic renal transplantation, including 5 females and 20 males aged 20-67 (mean 43.3 years old). For determination of renal function glomerular filtration rate value has been determine using Cocroft-Gault and widely use Modification of Diet (MDRD) equation.
Results. Patients after allogenic renal transplantation after a 26-week follow-up period reached CKD stage 2 according to NKF with the mean value of glomerular filtration rate GFR = 61.91 ml/min/1.73 m² (according to MDRD) and 73.46 ml/min (according to Cockroft-Gault).
Conclusion. The successful kidney transplantation is not corresponding with normal renal function achievement. The estimated GFR obtained with the Cockcroft-Gault equation was consistently higher than that from the MDRD equationin patients with after renal transplantation.
References
1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu C. Chronic kidney disease and the risk of death, cardiovascular events, and hospitaliza- tion. N Eng J Med. 2004;351:196-305.
2. Yang Q, Zhao S, Chen W, Mao H, Huang F, Zheng Z, Chen L, Fei J, Yu X. Influence of dialysis modality on renal transplant complications and outcomes. Clin Nephrol. 2009;72:62-8.
3. Joseph JT, Jindal RM. Influence of dialysis on post-transplant events. Clin Transplant. 2002;16:18-23.
4. Marcén R. Cardiovascular risk factors in renal transplantation – current controversies. Nephrol Dial Transplant. 2006;21:iii3-iii8.
5. Coresh J, Stevens LA. Kidney function estimating equations: where do we stand? Curr Opin Nephrol Hypertens. 2006;15:276-84.
6. Costa de Oliveira CM, Mota MU, Mota RS. Prevalence and staging of chronic kidney disease in renal transplant recipients. Clin Transplant. 2009;23:628-36.
7. Hermsen ED, Maiefski M, Florescu MC, Qiu F, Rupp ME. Compari- son of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for dosing antimicrobials. Pharmacotherapy. 2009;29:649- 55.
8. Moreso F, Grinyo JM. Graft dysfunction and cardiovascular risk – an unholy alliance. Nephrol Dial Transplant. 2007;22:699-702.
9. Gill JS, Tonelli M, Mix CH, Pereira BJ. The change in allograft function among long-term kidney transplant recipients. J Am Soc Nephrol. 2003;14:136-42.
10. Bertoni E, Rosati A, Larti A, Merciai C, Zanazzi M, Rosso G, Gal- lo M, Marcucci R, Salvadori M. Chronic kidney disease is still present after renal transplantation with excellent renal function. Transplant Proc. 2006;38:1024-5.
11. Grinyó JM. Steroid sparing strategies in renal transplantation Nephrol Dial Transplant. 2005;20:2028-31
