Affective disorders and self-injurious behavior in children and young adults with carbohydrate metabolism disorders

Authors

DOI:

https://doi.org/10.12923/2353-8627/2024-0010

Keywords:

affective disorder, depression, suicide, diabetes mellitus, children

Abstract

Introduction: Affective disorders and carbohydrate metabolism disorders are problems of increasing importance in the population of children, teenagers and young adults. Much evidence indicates that these problems may co-occur with increased frequency and have much more serious consequences than on their own.

Material and methods: Inclusion criteria were established for the review of studies and comprised participants under 25 years of age diagnosed with carbohydrate metabolism disorders, psychometric measurements of symptoms of affective disorders and self-aggressive tendencies. Review of the MEDLINE database was conducted.

Discussion: The results of 10 out of 12 studies included in the review indicated significantly increased risk of depression and suicidal tendencies in patients with diabetes. In the described publications, the frequency of affective disorders in a specific population ranged from 1.2% to 47.6% and up to 60.4% for unspecified affective disorder, sub-threshold and fully symptomatic, and the HR ranged from 1.33 to 2.0 for fully symptomatic affective disorders and up to 6.49 for unspecified affective disorder, sub-threshold and fully symptomatic. Descriptions of the incidence of self-injurious behavior and suicidal tendencies estimate them in the range from 0.8% to 35.7%, and in the studies comparing to a control group, the risk for a suicide attempt was between HR: 1.7 and 3.25.

Conclusions: The occurrence of affective disorders in children and young adults is significantly more frequent in patients with diabetes compared to patients without carbohydrate metabolism disorders.

References

1. Racine N, McArthur BA, Cooke JE, Eirich R, Zhu J, Madigan S. Global Prevalence of Depressive and Anxiety Symptoms in Children and Adolescents During COVID-19: A Meta-analysis. JAMA Pediatr. 2021 Nov 1;175(11):1142. Review match

2. Grey M, Whittemore R, Tamborlane W. Depression in type 1 diabetes in children: natural history and correlates. J Psychosom Res. 2002 Oct;53(4):907–11. Review match

3. Ward ZJ, Yeh JM, Reddy CL, Gomber A, Ross C, Rittiphairoj T, et al. Estimating the total incidence of type 1 diabetes in children and adolescents aged 0–19 years from 1990 to 2050: a global simulation-based analysis. Lancet Diabetes Endocrinol. 2022 Dec;10(12):848–58. Review match

4. Perng W, Conway R, Mayer-Davis E, Dabelea D. Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic. Diabetes Care. 2023 Mar 1;46(3):490–9. Review match

5. Mazze RS, Lucido D, Shamoon H. Psychological and Social Correlates of Glycemic Control. Diabetes Care. 1984 Jul 1;7(4):360–6. Review match

6. Kaminer Y, Robbins DR. Insulin misuse: a review of an overlooked psychiatric problem. Psychosomatics. 1989 Winter;30(1):19–24. Review match

7. Boileau P, Aboumrad B, Bougnères P. Recurrent comas due to secret self-administration of insulin in adolescents with type 1 diabetes. Diabetes Care. 2006 Feb;29(2):430–1. Review match

8. Butwicka A, Frisén L, Almqvist C, Zethelius B, Lichtenstein P. Risks of psychiatric disorders and suicide attempts in children and adolescents with type 1 diabetes: a population-based cohort study. Diabetes Care. 2015 Mar;38(3):453–9. Review match

9. Perry BI, Khandaker GM, Marwaha S, Thompson A, Zammit S, Singh SP, et al. Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort. Psychol Med. 2020 Mar;50(4):556–65. Review match

10. Sinnamon GCB, Caltabiano M, Baune BT. Differentiating disordered affect in children and adolescents with type 1 diabetes. J Affect Disord. 2013 May;147(1–3):51–8. Review match

11. Helgeson VS, Snyder PR, Escobar O, Siminerio L, Becker D. Comparison of adolescents with and without diabetes on indices of psychosocial functioning for three years. J Pediatr Psychol. 2007 Aug;32(7):794–806. Review match

12. Efe YS, Erdem E. A Comparison of Aggression and Self-injury Among Type 1 Diabetic and Healthy Adolescents: A Sample From Turkey. Arch Psychiatr Nurs. 2018 Apr;32(2):174–9. Review match

13. Vila G, Robert JJ, Nollet-Clemencon C, Vera L, Crosnier H, Rault G, et al. Eating and emotional disorders in adolescent obese girls with insulin-dependent diabetes mellitus. Eur Child Adolesc Psychiatry. 1995 Oct;4(4):270–9. Review match

14. Kovacs M, Goldston D, Obrosky DS, Bonar LK. Psychiatric disorders in youths with IDDM: rates and risk factors. Diabetes Care. 1997 Jan;20(1):36–44. Review match

15. Robinson ME, Simard M, Larocque I, Shah J, Nakhla M, Rahme E. Risk of Psychiatric Disorders and Suicide Attempts in Emerging Adults With Diabetes. Diabetes Care. 2020 Feb;43(2):484–6. Review match

16. Roberts AJ, Bao H, Qu P, Moss A, Kim G, Yi-Frazier JP, et al. Mental health comorbidities in adolescents and young adults with type 2 diabetes. J Pediatr Nurs. 2021 Dec;61:280–3. Review match

17. Radobuljac MD, Bratina NU, Battelino T, Tomori M. Lifetime prevalence of suicidal and self-injurious behaviors in a representative cohort of Slovenian adolescents with type 1 diabetes. Pediatr Diabetes. 2009 Nov;10(7):424–31. Review match

18. Cooper MN, de Klerk NH, Jones TW, Davis EA. Clinical and demographic risk factors associated with mortality during early adulthood in a population-based cohort of childhood-onset type 1 diabetes. Diabet Med J Br Diabet Assoc. 2014 Dec;31(12):1550–8. Review match

19. Majidi S, O’Donnell HK, Stanek K, Youngkin E, Gomer T, Driscoll KA. Suicide Risk Assessment in Youth and Young Adults With Type 1 Diabetes. Diabetes Care. 2020 Feb;43(2):343–8. Review match

20. Buchberger B, Huppertz H, Krabbe L, Lux B, Mattivi JT, Siafarikas A. Symptoms of depression and anxiety in youth with type 1 diabetes: A systematic review and meta-analysis. Psychoneuroendocrinology. 2016 Aug;70:70–84. Review match

21. Zhang J, Sun R, Cai Y, Peng B, Yang X, Gao K. Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder and Bipolar Depression: A Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials. J Clin Med. 2024 Jan;13(4):1172.

Downloads

Published

2025-01-09