Role of chlorhexidine in adhesion to dentin
DOI:
https://doi.org/10.12923/j.2084-980X/25.4/a.06Keywords:
adhesion, dentin, chlorhexidine, CHX, metalloproteinase , MMPAbstract
The authors, basing on literature discuss the role of chlorhexidine (CHX) in adhesion to dentine in restorative dentistry. Many studies have shown that the chlorhexidine has an inhibitory effect on metalloproteinases (MMPs), by preventing the degradation of the connection between bonding system and a dentin. Despite the introduction of additional procedure in the form of disinfection of the cavity using chlorhexidine and thus the extension of the valuable chair-time, the fact of preventing microleakage and secondary caries seems to be convincing but further detailed studies must be carried out in this area.
References
1. Breschi L. et al.: Chlorhexidine stabilizes the adhesive interface: a 2-year in vitro study. Dent. Mater., 26, 320, 2010.
2. Breschi L. et al.: Dental adhesion review: aging and stability of the bonded interface. Dent. Mater., 24, 90, 2008.
3. Burdan F. et al.: Morphology and physiology of the epiphyseal growth plate. Folia Histochem. Cytobiol., 47, 5, 2009.
4. Campos E.A. et al.: Chlorhexidine diminishes the loss of bond strength over time under simulated pulpal pressure and thermo-mechanical stressing. J. Dent., 37,108, 2009.
5. Chaharom M.E.E. et al.: Effect of chlorhexidine on the shear bond strength of self-etch adhesives to dentin. Afr. J. Biotechnol., 49, 10054, 2011.
6. Chaussain-Miller C. et al.: The role of matrix metalloproteinases (MMPs) in human caries. J. Dent. Res., 85, 22, 2006.
7. De Munck J. et al.: Enzymatic degradation of adhesive-dentin interfaces produced by mild self-etch adhesives. Eur. J. Oral Sci., 118, 494, 2010.
8. Gendron R. et al.: Inhibition of the activities of matrix metalloproteinases 2, 8 and 9 by chlorhexidine. Clin. Diagn. Lab. Immunol., 6, 437, 1999.
9. Lipka D., Boratyński J.: Metaloproteinazy MMP. Struktura i funkcja. Postepy Hig. Med. Dosw. (online), 62, 328, 2008.
10. Mazzoni A. et al.: Reactivation of inactivated endogenous proteolytic activities in phosphoric acid-etched dentine by etch-and-rinse adhesives. Biomaterials, 27, 4470, 2006.
11. Mjör I.A., Gordan V.V.: Failure, repair, refurbishing and longevity of restorations. Oper. Dent., 27, 528, 2002.
12. Mjör I.A. et al.: Placement and replacement of restorations in general dental practice in Iceland. Oper. Dent., 27, 117, 2002.
13. Nergelo Newton A.P. et al.: New data on biological effects of chlorhexidine: Fe2+ induced lipid peroxidation and mitochondrial permeability transition. Toxicol. Lett., 151, 407, 2004.
14. Nishitani Y. et al.: Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives. Eur. J. Oral Sci., 114, 160, 2006.
15. Pashley D.H., Tay F.R., Imazato S.: How to increase the durability of resin-dentin bonds. Compend. Contin. Educ. Dent., 32, 60, 2011.
16. Punke Ch. et al.: Matrix change of bone grafting substitute after implantation into guinea pig bulla. Folia Morphol. (Warsz.), 71, 109, 2012.
17. Ricci H.A. et al.: Chlorhexidine increases the longevity of in vivo resin-dentin bonds. Eur. J. Oral Sci., 118, 411, 2010.
18. Sadek F.T. et al.: Ethanol wet-bonding challenges current anti-degradation strategy. J. Dent. Res., 89, 1499, 2010.
19. Sekhon B.S.: Matrix metalloproteinases – an overview. Res. Rep. Biol., 1, 1, 2010.
20. Soares C.J. et al.: Effect of chlorhexidine application on microtensile bond strength to dentin. Oper. Dent., 33, 183, 2008.
21. Sulkala M.: Matrix metalloproteinases (MMPs) in the dentin-pulp complex of healthy and carious teeth. Oulu University Press, Oulu 2004.
22. Szewczenko J., Obersztyn I., Krawczyk A.: Sposoby adhezji systemów wiążących do zębiny – przegląd materiałów na podstawie piśmiennictwa. Porad. Stomatol., 6, 176, 2008.
23. Szpak A.: Przegląd systemów adhezyjnych na podstawie piśmiennictwa. Część I. Mag. Stom., 207, 47, 2009.
24. Tezvergil-Mutluay A. et al.: The inhibitory effect of polyvinylphosphonic acid on functional matrix metalloproteinase activities in human demineralized dentin. Acta Biomater., 10, 4136, 2010.
25. Tezvergil-Mutluay A. et al.: The inhibitory effects of quaternary ammonium methacrylates on soluble and matrix bound MPPs. J. Dent. Res., 90, 535, 2011.
26. Wojtowicz-Praga S.M., Dickson R.B., Hawkins M.J.: Matrix metalloproteinase inhibitors. Invest. New Drugs, 15, 61, 1997.
27. www.bisco.com
Downloads
Published
Issue
Section
License
Copyright (c) 2012 Authors
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.
