Vol. 22 No. 3 (2009), Artykuły
Vol. 22 No. 3 (2009)

Novel aspects of melatonin-induced defence on oral mucosaduring experimental erosive esophagitis

Artykuły
Published 2009-09-30
Stephan Yaciv
Danylo Halytskyi Lviv National Medical University, Normal Physiology Department
Oksana Zayachkivska
Danylo Halytskyi Lviv National Medical University, Normal Physiology Department
Mechyslav Gzhegotsky
Danylo Halytskyi Lviv National Medical University, Normal Physiology Department

Abstract

We studied the morphofunctional changes in oral mucosa lesions during the experimental еrosive esophagitis induced by acid-pepsin perfusion and modification of PG/COX activity and melatonin treatment. Melatonin-treatment enhanced epithelial proliferation and accelerated healing in foregut mucosa. Melatonin is a likely mediator of oral mucosa cytoprotection and ulcer healing due to diminished endothelial dysfunctions.

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