Novel aspects of melatonin-induced defence on oral mucosaduring experimental erosive esophagitis

Authors

  • Stephan Yaciv Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author
  • Oksana Zayachkivska Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author
  • Mechyslav Gzhegotsky Danylo Halytskyi Lviv National Medical University, Normal Physiology Department Author

Abstract

We studied the morphofunctional changes in oral mucosa lesions during the experimental еrosive esophagitis induced by acid-pepsin perfusion and modification of PG/COX activity and melatonin treatment. Melatonin-treatment enhanced epithelial proliferation and accelerated healing in foregut mucosa. Melatonin is a likely mediator of oral mucosa cytoprotection and ulcer healing due to diminished endothelial dysfunctions.

References

1. Baatar D. et al.: Esophageal ulceration activates genes encoding keratinocyte growth factor and its receptor in rats: A key to esophageal ulcer healing? Gastroenterology, 122, 458, 2002.

2. Cutando A. et al.: Melatonin: potential functions in the oral cavity. J. Periodontol., 78(6), 1094, 2007.

3. Czesnikiewicz-Guzik M. et al.: Melatonin and its role in oxidative stress related diseases of oral cavity. JPP, 58 (3), 5, 2007.

4. Dean B. B. et al.: Night-time and daytime atypical manifestations of gastro-oesophageal reflux disease: frequency, severity and impact on health-related quality of life. Aliment. Pharmacol. Ther., 27(4), 327, 2008.

5. Konturek S. J. et al.: Role of melatonin in upper gastrointestinal tract. JPP, 58 (6), 23, 2007.

6. Nagy G.: Role of saliva, salivary glands and epidermal growth factor (EGF) on oral wound healing. Fogorv. Sz., 96, 1, 17, 2003.

7. Namiot Z. et al.: Modulatory effect of esophageal intraluminal mechanical and chemical stressors on salivary prostaglandin E2 in humans. Am. J. Med. Sci., 313(2), 90, 1997.

8. Oda Y. et al.: Accelerating effects of basic fibroblast growth factor on wound healing of rat palatal mucosa. J. Oral Maxil. Surg., 62, 1, 73, 2004.

9. Oginni A. O. et al.: The prevalence of dental erosion in Nigerian patients with gastrooesophageal reflux disease. BMC Oral Health, 92, 98, 2005.

10. Oh D. S. et al.: The impact of reflux composition on mucosal injury and esophageal function. J. Gastrointest. Surg. 10 (6), 787, 2006.

11. Shunji S.: Host defense of oral mucosa and the molecular mechanism of oral mucosal signal transduction diseases. J. Oral Biosci., 47 (2), 115, 2005.

12. Tarnawski A. et al.: Aging gastropathy – novel mechanisms: hypoxia, upregulation of multifunctional phosphatase PTEN and proapoptotic factors. Gastroenterology, 133(6), 1938, 2007.

13. Yaciv S. et al.: Multyfynkcionalna rol’ NO v stress-indukovanyh urajennyah slyzovoj yasen (experymental’ne modeluvannya). EPB, 1, 41, 2006.

14. Zayachkivska O. et al.: Protective influence of melatonin against acute esophageal lesions involves prostaglandins, nitric oxide and sensory nerves. JPP, 58(2), 361, 2007.

Volume XXII, 3

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Published

2009-09-30

Issue

Vol. 22 No. 3 (2009): Annales UMCS, Pharmacia, Sectio DDD, Volume XXII

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Artykuły

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