Vol. 22 No. 3 (2009), Artykuły
Vol. 22 No. 3 (2009)

Activity of membrane-bound enzymes of rat hepatocyte plasmamembrane under the influence of pyridine and pyridoxine (vitamin B6)

Artykuły
Published 2009-09-30
Svitlana Yablonska
National Taras Shevchenko University of Kyiv, Department of Cytophysiology
Volodymyr Lozovyy
Medical Institute of Ukrainian Folk Medicine Association, Department of Medical Biology, Kyiv
Olena Filinska
National Taras Shevchenko University of Kyiv, Department of Cytophysiology
Galyna Ostrovska
National Taras Shevchenko University of Kyiv, Department of Cytophysiology
Taras Rybalchenko
National Taras Shevchenko University of Kyiv, Department of Cytophysiology
Victoria Zelenyuk
National Taras Shevchenko University of Kyiv, Department of Cytophysiology
Volodymyr Rybalchenko
National Taras Shevchenko University of Kyiv, Department of Cytophysiology

Abstract

Enzymes’ activity of hepatocyte plasma membrane was studied under the infl uence of pyridine and pyridoxine in the concentratin range 10-9-10-4 M. The studied substances reveal membrane effects that depend on their ability for interaction with membrane lipid matrix. Those substances do not disturb 5′-nucleotidase, ecto-ATPase activity signifi cantly, but produce alteration of Mg2+, Ca2+- and Na+, K+-ATPase activity of hepatocytes plasma membrane. A different response of Mg2+, Ca2+- and Na+, K+-ATPase activity to the infl uence of pyridine and pyridoxine might depend on their structure.

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