Activity of membrane-bound enzymes of rat hepatocyte plasmamembrane under the influence of pyridine and pyridoxine (vitamin B6)

Authors

  • Svitlana Yablonska National Taras Shevchenko University of Kyiv, Department of Cytophysiology Author
  • Volodymyr Lozovyy Medical Institute of Ukrainian Folk Medicine Association, Department of Medical Biology, Kyiv Author
  • Olena Filinska National Taras Shevchenko University of Kyiv, Department of Cytophysiology Author
  • Galyna Ostrovska National Taras Shevchenko University of Kyiv, Department of Cytophysiology Author
  • Taras Rybalchenko National Taras Shevchenko University of Kyiv, Department of Cytophysiology Author
  • Victoria Zelenyuk National Taras Shevchenko University of Kyiv, Department of Cytophysiology Author
  • Volodymyr Rybalchenko National Taras Shevchenko University of Kyiv, Department of Cytophysiology Author

Abstract

Enzymes’ activity of hepatocyte plasma membrane was studied under the infl uence of pyridine and pyridoxine in the concentratin range 10-9-10-4 M. The studied substances reveal membrane effects that depend on their ability for interaction with membrane lipid matrix. Those substances do not disturb 5′-nucleotidase, ecto-ATPase activity signifi cantly, but produce alteration of Mg2+, Ca2+- and Na+, K+-ATPase activity of hepatocytes plasma membrane. A different response of Mg2+, Ca2+- and Na+, K+-ATPase activity to the infl uence of pyridine and pyridoxine might depend on their structure.

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Volume XXII, 3

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Published

2009-09-30

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Vol. 22 No. 3 (2009): Annales UMCS, Pharmacia, Sectio DDD, Volume XXII

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