Methicillin-resistant Staphylococcus aureus (MRSA) – ,,neverending story”
DOI:
https://doi.org/10.12923/Abstract
Staphylococcus aureus is one of the most common human pathogens causing hospital- and community-acquired infections. Methicillin-resistant strains of S. aureus (MRSA) make a therapeutic problem due to their resistance to all of the beta-lactam antibiotics, often accompanied by resistance to other groups of antibiotics (called as multiresistance). The mechanism of methicillin-resistance is associated with an acquisition of mecA gene encoding modified enzymatic protein (PBP2a), which is responsible for biosynthesis of peptidoglycan in bacterial cell wall, despite the presence of beta-lactams in the environment. For many years the problem with MRSA has been restricted to hospitalized patients; strains isolated in the hospital are called as HA-MRSA (hospital-acquired MRSA). However, in recent years new groups of MRSA called as CA-MRSA (community-acquired MRSA) and FA-MRSA (farm-associated MRSA) have been isolated in the community. Recently, new antibiotics with potential activity against MRSA such as linezolid and daptomycin have been introduced for treatment of infectious diseases.
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