Natural inhibitors of metalloproteinases from fungi and herbs – new bioactive extracts of pharmacological potential
Keywords:
wood rotting fungi, herbs, metalloproteinase inhibitors, matrix metalloproteinases, MMPsAbstract
Novel metalloproteinase inhibitors were extracted from the fruit bodies of a few wood rotting fungi and some herbs. Fractions active against metalloproteases was extracted with chloroform and, for comparison, with other organic solvents. Their inhibitory parameters were characterized against gelatinase and collagenase activities. In the course of searching for potential pharmacological activities, inhibition of MMP1, MMP2, MMP3 and MMP9 were analyzed. The obtained results suggest that isolated substances are similar to berberine (substances from herbs) and polyporenic acids from Piptoporus betulinus (substances from wood rotting fungi). They are very promising bioactive substances (few extracts are really very active, in comparison with literature data).
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