Effect of maleimide derivative on oxidative stress and glutathione antioxidant system in 1,2-dimethylhydrazine induced colon carcinogenesis in rat

Authors

  • Olena Filinska Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author
  • Svitlana Yablonska Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author
  • Sergiy Mandryk Taras Shevchenko National University of Kyiv, Department of Biochemistry Author
  • Iryna Kharchuk Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author
  • Iryna Kotlyar Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author
  • Galyna Ostrovska Department of Cytology, Histology and Developmental Biology, Taras Shevchenko National University of Kyiv, Ukraine Author
  • Volodymyr Rybalchenko Taras Schevchenko National University of Kyiv, Department of Cytophysiology Author

DOI:

https://doi.org/10.12923/

Keywords:

maleimide derivative, 1,2-dimethylhydrasine, colon cancer, oxidative stress

Abstract

The levels of protein carbonyl groups, thiobarbituric acid reactive substances (TBARS), reduced glutathione, and glutathione-dependent enzymes, and c-kit expression in intestinal mucosa of rats after treatment with maleimide derivative 1-(4-Cl-benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2.5-dione (MI-1) in doses 0.027 and 2.7 mg/kg have been studied. Colon cancer was induced by 1,2-dimethylhydrazine (DMH). The increase of the level of TBARS and protein carbonyl groups and glutathione antioxidant system in DMH-treated rats was shown. MI-1 restores changes of the studied parameters and blocks c-kit expression in intestinal mucosa of DMH-treated rats.

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Published

2010-09-30

Issue

Vol. 23 No. 3 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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