Red wine counteracts nitrative stress and PARP-1 overactivation in the retina of diabetic rats

Authors

  • Viktor Drel Department of Biochemistry, Ivan Franko National University Author
  • Anatoliy Yalaneckyy National Institute for Vine and Wine “Magarach”, Ukraine Author
  • Volodymyr Mizin National Institute for Vine and Wine “Magarach”, Ukraine Author
  • Viktor Zagoruyko National Institute for Vine and Wine “Magarach”, Ukraine Author
  • Viktoria Gerzhykova National Institute for Vine and Wine “Magarach”, Ukraine Author
  • Nataliya Sybirna Department of Biochemistry, Ivan Franko National University Author

Keywords:

diabetes retinopathy, polyphenols, oxidative-nitrative stress, poly(ADP-ribose) polymerase

Abstract

Increased accumulation of nitrotyrosine and poly(ADP-ribosyl)ated proteins in the tissues of diabetics are associated with diabetes complications (diabetes neuropathy, nephropathy and retinopathy). The present study showed that red wine decreases the level of nitrotyrosine modified and poly(ADP-ribosyl)ated proteins in the retinae of diabetic rats to the control level. This data allows us to assume an important role of red wine and its polyphenols preparation in the prevention and treatment of diabetic complications.

References

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Published

2010-12-30

Issue

Vol. 23 No. 4 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

License

Copyright (c) 2025 Viktor Drel, Anatoliy Yalaneckyy, Volodymyr Mizin, Viktor Zagoruyko, Viktoria Gerzhykova, Nataliya Sybirna (Autor)

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported License.