Lipophilicity of natural coumarines

Authors

  • Dariusz Matosiuk Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Faculty of Pharmacy, Medical University of Lublin Author https://orcid.org/0000-0002-2373-9479
  • Daniel Gralak Main Pharmaceutical Inspectorate, Warsaw Author
  • Marta Ryznar Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Faculty of Pharmacy, Medical University of Lublin Author

Keywords:

natural coumarins, lipophilicity, partition coefficient, logP, RP-TLC, lipophilicity standards

Abstract

Coumarins are the class of natural compounds found in many medicinal plants with broad spectrum of activity. Many of them are also used as pharmaceutical substances, so there is an urgent need for efficient method of their isolation from the natural sources. Classical, extraction methods allow only isolation of the coumarin fraction, without separation of the elements of the mixture. It is caused mostly by coumarins small structural differences, affecting weekly their retention behavior. The parameter which ore directly can differentiate coumarins could be their lipophilicity. To confirm that, the measurement of the lipophilicity of the coumarin series by RP TLC method was performed in different eluent systems with standardization. Results confirmed great differences in lipophilicity of coumarins and also usefulness of the reversed-phase chromatography for separation of particular ones.

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Annales Sectio DDD, XXIV, 2

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Published

2012-01-09

Issue

Vol. 24 No. 2 (2011): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIV

Section

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How to Cite

Matosiuk, D., Gralak, D., & Ryznar, M. (2012). Lipophilicity of natural coumarines. Current Issues in Pharmacy and Medical Sciences, 24(2), 19-25. https://czasopisma.umlub.pl/curipms/article/view/3000