Influence of the concentration of oil phase on rheological properties of nonisotonic parenteral emulsions
Keywords:
fluidity, parenteral emulsions, rheology, thixotropyAbstract
Five emulsions were made of soybean oil, human albumin and lecithin-in fixed amounts and water - in decreasing amounts. They were prepared aseptically. After homogenization the rheological measurements were carried out using a rotational viscometer "Rheotest 2". Knowing the shear stress values (Tr) at the corresponding values of shear rates (Dr), the dynamic viscosity was calculated (η), and then the fluidity (ф ) of analyzed preparations which are presented in figures as a function of ф = f(DrN).
Studies indicate that these systems are characterized by pseudoplastic flow andthey show thixotropy, which increases with decreasing water phase. Their fluidity can be described by the general equation ф = K(DrN), where: K - speed fluidization, Dr - shear stress, N - power exponent.
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