The preparation of suppositories by various methods and evaluation of physicochemical properties
Keywords:
suppository bases, surfactants, paracetamolAbstract
The preparation suppositories containing 250 mg of paracetamol on different bases using Cocoa butter, Novata BD, Novata BCF and mixture of Novata BCF: BD (1:1). Suppositories containing base Cocoa butter were prepared by the melting method, in the press and in the unguator. Suppositories containg bases Novata BD, BCF and mixture were prepared by the melting method. The prepared formulations with or without surfactants (Tween 60, Span 80) at concentrations of 5% (w/w) were tested for hardness, metting time, content uniformity and release of the drug. The relase of the drug was carried in the apparatus with the stirrer shade in phosphate buffer (pH 7.2) at 100 rpm. The physical properties of the prepared suppositories were responded to requirements Polish Pharmacopoeia 8 th edition. The results showed that addition of 5 % Tween 60 increased the the drug of release from all the investigated formulae independently of the method of preparation.Whereas addition of Span 80 had not significant effect on the release profiles.
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