Some biochemical parameters of kidney functionin rats after acute poisoning with tin chloride

Iwona Piątkowska-Chmiel; Magdalena Izdebska

Authors

Iwona Piątkowska-Chmiel Department of Toxicology, Medical University of Lublin, Poland Author https://orcid.org/0000-0003-1829-6981
Magdalena Izdebska Department of Toxicology, Medical University of Lublin, Poland Author https://orcid.org/0000-0001-5999-4300

Keywords:

acute tin chloride intoxication, rats, biochemical parameters, damage of kidney function

Abstract

Kidney is the main target organ for many heavy metals. The toxic effect of tin on kidneys is still not clear. The aim of this study was to assess the function of kidneys in rats acutely intoxicated by tin chloride. The study was carried out on male Wistar rats. Animals were given intraperitioneally (ip) tin chloride in a dose of 63.2 mg/kg b.w. After 48 h or 11-days from acute intoxication, the rats were decapitated and blood was collected. Ready-made diagnostic kits were used for biochemical measurements: urea, creatinine and beta-2 microglobulin in the blood serum. Forty eight hours after acute intoxication with tin chloride, significantly increased concentration of urea and creatinine, and not beta-2-microglobulin in the serum of rats, was observed. However, after 11 days from acute tin chloride intoxication, only significantly increased concentration of beta-2-microglobulin in the serum of rats was observed. Acute tin chloride intoxication of rats can damage the function of kidney.

References

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Some biochemical parameters of kidney functionin rats after acute poisoning with tin chloride

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