The etiopathology and prophylaxis of serologic incompatibility

Abstract

Serologic incompatibility composes the risk of fetus haemolytic disease occurrence. It can produce high risk for normal fetus development and newborn life conditions, depending on its severity. Decrease in frequency of the serologic incompatibility was observed with the popularisation of this pregnancy complication prophylaxis. However, there was a number of reasons influencing the fact that the problem has not been solved yet. The method of preventing immunisation was evolved on the basis of observation of the penetration of the foetus blood cells into the mother blood circulation system, and the conditions in which antibodies against Rh blood groups antigens are formed. The mechanism of IgG anti-D has not been explained yet. However, it can be assumed that the protective effect against immunisation is obtained when there is the excess of antibodies in comparison to the amount of antigen.
Lowering the frequency of RhD alloimmunisation is the prototype of the effectiveness of medical prophylaxis. The use of IgG anti-D in the 28th-week pregnancy is not comprised by all-national standards.