Abstract
ADHERENCE TO DIETARY RECOMMENDATIONS BY CHILDREN AND ADOLESCENTS DURING STEROID THERAPY IN ACUTE LYMPHOBLASTIC LEUKEMIA
Aim. Assessment of adherence to dietary recommendations by children and adolescents during steroid therapy in the treatment of acute lymphoblastic leukemia (ALL).
Material and methods. The study was conducted among parents of children with ALL, aged from 1 to 17 years, treated at the Department of Paediatrics, Hematology and Oncology of the University Clinical Centre in Gdańsk. The paper uses the method of a diagnostic survey, the questionnaire technique. The research tool was an anonymous self-constructed questionnaire.
Results. The study included 16 parents (44.4%) of female children and 20 parents (55.6%) of male children. Normal body weight was found in most of the children (22/36 children). Grade 1 hypertension was found in 15/36 children and grade 2 hypertension in 6/36. In 31/36 children, the blood glucose level was 70-180 mg%. The number of 22/36 examined children used a diet with a low glycemic index. As many as 29/36 parents of children and adolescents with ALL followed the diet recommended by a doctor.
Conclusions. 1) Most children with ALL have normal body weight during steroid therapy. 2) Children with ALL are subject to arterial hypertension during steroid therapy. 3) Most parents or legal guardians of children and adolescents with ALL adhered to dietary recommendations during steroid therapy.
References
1. Pegon Ch, Rochette E, Rouel N, et al. Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study, J Clin Med. 2020;9(2): 562, DOI: 10.3390/jcm9020562
2. Derwich K, Zając-Spychała O. Zaburzenia genetyczne w ostrej białaczce limfoblastycznej u dzieci i ich wykorzystanie w praktyce klinicznej. Hematologia. 2012;3(3): 221-230.
3. Mały E, Przyborska M, Derwich K, et al. Zmiany cytogenetyczne a pozostałe czynniki prognostyczne u dzieci z ostrą białaczką limfoblastyczną - badania jednoośrodkowe. Acta Haematologica Polonica. 2011;42(3): 507-512.
4. Bulas M, Pierlejewski F, Młynarski W. Glikokortykosteroidooporność w chorobach limfoproliferacyjnych u dzieci. Przegląd pediatryczny. 2009;39(1):57-61.
5. Li R, Donnella H, Knouse P, et al. A randomized nutrition counseling intervention in pediatric leukemia patients receiving steroids results in reduced caloric intake. Pediatr Blood Cancer. 2017;64:374-380. DOI: 10.1002/pbc.26231
6. Reilly JJ, Brougham M, Montgomery C, et al. Eff ect of Glucocorticoid Therapy on Energy Intake in Children Treated for Acute Lymphoblastic Leukemia. The Journal of Clinical Endocrinology & Metabolism. 2001;86(8):3742-3745. DOI: 10.1210/jcem.86.8.7764
7. Marchewka Z, Guzy K, Robach-Dolata A, et al. Leki jako czynniki ryzyka rozwoju hiperglikemii oraz mechanizmy ich działania diabetogennego. Farm Pol. 2017;73(2): 105-114.
8. Esbenshade AJ, Simmons JH, Koyama T, et al. Body mass index and blood pressure changes over the course of treatment of pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011;56:372-378. DOI: 10.1002/pbc.22782
9. Kułaga Z, Rożdżyńska-Świątkowska A, Grajda A, et al. Siatki centylowe dla oceny wzrastania i stanu odżywienia polskich dzieci i młodzieży od urodzenia do 18 roku życia. Standardy Medyczne. Pediatria. 2015;12:119-135.
10. www.cdc.gov/growthcharts, accessed on: 04.07.2020 14. Flynn JT, Kaelber DC, Baker-Smith CM, et al. Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Pediatrics 2017;140(3): e20171904. DOI: 10.1542/peds.2017-1904
11. Pisarczyk-Wiza D, Zozulińska-Ziołkiewicz D. Glikokortykosteroidy a zaburzenia metabolizmu glukozy. Diabetologia Kliniczna. 2015;4(3): 110-116.
12. Banecka B, Lesiuk M, Beń-Skowronek I, et al. Przejściowe zaburzenia gospodarki węglowodanowej w czasie intensywnego leczenia ostrej białaczki limfoblastycznej u dzieci. Endokrynologia Pediatryczna. 2013;3 (44): 47-52.
13. Hijiya N, van der Sluis I. Asparaginase-associated toxicity in children with acute lymphoblastic leukemia, Leukemia & Lymphoma. 2016;57(4):748-757. DOI: 10.3109/10428194.2015.1101098
14. Lowas SR, Marks D, Malempati S. Prevalence of transient hyperglycemia during induction chemotherapy for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2009;52: 814-818. DOI 10.1002/pbc.21980
15. Aisyi M, Andriastuti M, Kurniati N. The Eff ect of Combination of Steroid and L-Asparaginase on Hyperglycemia in Children with Acute Lymphoblastic Leukemia (ALL), Asian Pac J Cancer Prev. 2019;1;20(9):2619-2624. DOI: 10.31557/APJCP.2019.20.9.2619
16. Jansen H, Postma A, Stolk RP, Kamps WA. Acute lymphoblastic leukemia and obesity: increased energy intake or decreased physical activity? Support Care Cancer. 2009;17(1):103-106. DOI: 10.1007/s00520-008-0531-0
17. Van Dongen-Melman JEWM, Hokken-Koelega ACS, Hahlen K, et al. Obesity after successful treatment of acute lymphoblastic leukemia in childhood. Pediatric Research 1995;38 (1): 86-90. DOI: 10.1203/00006450-199507000-00015
18. Iughetti L, Bruzzi P, Predieri B, et al. Obesity in patients with acute lymphoblastic leukemia in childhood. Italian Journal of Pediatrics. 2012;38 (4):2-11.
19. Veringa SJE, van Dulmen ‐ den Broeder E, Gertjan JL Kaspersky GJL, et al. Blood pressure and body composition in long‐term survivors of childhood acute lymphoblastic leukemia, Pediatr Blood Cancer 2012;58: 278-282, DOI: 0.1002/pbc.23251
20. Pegon Ch, Rochette E, Rouel N, et al. Childhood Leukemia Survivors and Metabolic Response to Exercise: A Pilot Controlled Study, J Clin Med. 2020;9(2):562, DOI: 10.3390/jcm9020562
21. Alias H, Mohd Nazi NA, Lau Sie Chong D. Participation in Physical Activity and Physical Education in School Among Children With Acute Lymphoblastic Leukemia After Intensive Chemotherapy, Front Pediatr. 2019;7: 73. DOI: 10.3389/fped.2019.00073
22. Beaulieu-Gagnon S, Belanger V, Meloche C. Nutrition education and cooking workshops for families of children with cancer: a feasibility study, BMC Nutr. 2019;19; 5:52. DOI: 10.1186/s40795-019-0319-2
23. Sonabend RY, McKay SV, Oncu MF, et al. Hyperglycemia during induction therapy is associated with increased infectious complications in childhood acute lymphocytic leukemia. Pediatr Blood Cancer. 2008;51: 387-392. DOI 10.1002/pbc.21624
24. O’Connor D, Bate J, Wade R. Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL 2003, Blood. 2014;124(7):1056-1061. DOI: 10.1182/blood-2014-03-560847
25. Weiser MA, Cabanillas ME, Konopleva M i wsp. Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen. Cancer. 2004;100 (6):1179-1185. DOI: 10.1002/cncr.20071.
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