Inflammatory changes in the oral mucosa as a side symptom of systemic treatment
Inflammatory changes in the oral mucosa as a side symptom of systemic treatment.pdf

Keywords

complications,
treatment
oral hygiene
oral mucositis
chemotherapy

Abstract

INFLAMMATORY CHANGES IN THE ORAL MUCOSA AS A SIDE SYMPTOM OF SYSTEMIC TREATMENT

Introduction. Introduction OM caused by systemic treatment is a major therapeutic problem. The related complications may causa complications in the course of planned treatment, which in turn may aff ect the prognosis and results of oncological treatment.

Aim. The aim of the study is to present the problem experienced by oncological patients undergoing systemic treatment.The paper describes the pathogenesis of oral mucositis, the current treat-ment standards and emphasizes the role of an oncology nurse in ca ring for a patient with symptoms of this disease.

Method. The paper reviews selected literature on stomatitis in cancer patients. Numerous clinical trials are conducted to search for drugs that could be used in the prevention and treatment – OM.

Summary. The development of oncological therapies, including targeted treatment and immunotherapy, signifi cantly extended the life span of patients and the time free from disease progression. Appropriate prophylaxis, patient education, systematic observation allow for early detection of the disease, which allows for quick implementation of symptomatic treatment. The basis of successful oncological therapy is close cooperation the patient with the doctor and nurse, and active and conscious participation in the en tire treatment and care proces.

Inflammatory changes in the oral mucosa as a side symptom of systemic treatment.pdf

References

1. http://onkologia.org.pl/nowotwory-zlosliwe-ogolem-2/.

2. Lionel D, Christophe L, Marc A, et al. Oral mucositis induced by anticancer treatments: physiopathology and treatments. Ther. Clin. Risk Manag. 2006; 2: 159-168.

3. Gibson RJ, Keefe DM, Lalla RV, et al. Systematic review of agents for the management of gastrointestinal mucositis in cancer patients. Support. Care Cancer. 2013; 21: 313­-326.

4. Lalla RV, Bowen J, Barasch A, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014; 120: 1453­1461.

5. Kashiwazaki H, Matsushita T, Sugita J, et al. Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation. Support. Care Cancer. 2012; 20: 367-373.

6. Olczak-Kowalczyk D, et al. Problemy stomatologiczne u dzieci z chorobami nowotworowymi. Doświadczenia własne. Nowa Stom. 2003; 4: 175-179.

7. Sidorowicz K, Sokalski J. Ambulatoryjne postępowanie stomatologiczne u pacjentów leczonych chemio- i radioterapią. Dental. Forum. 2007; 1(XXXV): 77-80.

8. Pleova P. Prevention and treatment of chemotherapy and radiotherapy induced oral mucositis: a review. Oral. Oncol. 1999; 35(5): 453-470.

9. Sonis ST. Mucositis: the impact, biology and therapeutic opportunities of oral mucositis. Sonis ST. Oral. Oncol. 2009; 45: 1015-1020.

10. Trotti A, Bellm LA, Epstein JB, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literaturę review. Radiother. Oncol. 2003; 66: 253-262.

11. Worthington HV, Clarkson JE, Bryan G, et al. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst. Rev. 2011(4): CD000978.

12. Woo SB, Somis ST, Monopoli M, et al. A longitudinal study of oral ulcerative mucositis in bone marrow trans plant recipients. cancer 1993; 72: 1612-1617.

13. Cioch M. Uszkodzenie bariery śluzówkowej w następstwie intensywnego leczenia cytostatycznego. Onkol. Pol. 2001; 4(2): 85-88.

14. Kuklińsky RF. Dental menagement of cancer patients. Chemotherapy consideration. Oncol. 2000; 15(4): 29-30.

15. Common Terminology Criteria for Adverse Events (Version 5.0). Dostęp on­line:10.01.2020(https://ctep.cancer.gov/protocoldevelopment/ electronic_ applications/docs/CTCAE_v5_Quick_Reference_5x7.pdf).

16. Potemski P, Czyżykowski R. Supportive care. Neutropenia. Oncol. Clin. Pract. 2020; 16.

17. Shaw MT, Spector MH, Ladman AJ. Effects of cancer, radiotherapy and cytotoxic drugs on intestinal structure and function. Cancer. Threat. Rev. 1979; 6: 141-151.

18. Mestecky J, Russel MW, Elson CO. Intestinal IgA: novel views on its function in the defence of the largest mucosal surface. Gut. 1999; 44: 2-5.

19. Petkowicz B, Jastrzębska I, Jamorogiewicz R. Zapalenie błony śluzowej w jamie ustnej jako powikłanie w chemioterapii. Samodzielna Pracownia Medycyny Jamy Ustnej Uniwersytet Medyczny w Lublinie.

20. Larson PJ, Miaskowski C, MacPhail L, et al. The Pro-SelF Mouth aware program: an effective approach for reducing chemotherapy-induced mucositis. Cancer Nurs. 1998; 21: 263-268.

21. WHO handbook for reporting the result of cancer treatment. WHO Offset Publications, Geneva, 1979.

22. Köstler WJ, Hejna M, Wenzel C, et al. Oral mucositis complicating chemotherapy and radiotherapy: options for prevention and treatment. CA Cancer J. Clin. 2001; 51(5): 290-315.

23. Krajewski W. Zagadnienia współczesnej profilaktyki stomatologicznej. Med. Tour Press International. Warszawa, 1995; 18, 53-55.

24. Pulito C, Cristaudo A, La Porta C, et al. Oral mucositis: the hidden side of cancer therapy. Journal of Experimental & Clinical Cancer Research. 2020; 39: 210.

25. Mędrzycka-Dąbrowska W, Dąbrowski S, Basiński A. Aktualne zalecenia w pielęgnacji jamy ustnej u pacjentów zaintubowanych i wentylowanych mechanicznie – przegląd piśmiennictwa. Anestezjologia i Ratownictwo. 2012; 6: 221-230.

26. Stec R, Smoter M, Deptała A i wsp. Onkologia. AsteriaMed. Wyd. 2. 2021, s. 71-72.

27. Peterson DE, Boers-Doets CB, Bensadoun RJ, et al. ESMO Guidelines Committee. Management of oral and gastrointestinal mucosal injury: ESMO Clinal Practice Guidelines for diagnosis, treatment, and follow-up. Ann. Oncol. 2015; 26 (5): v139-v151.

28. Basile D, Di Nardo P, Corvaja C, et al. Mucosal injury during anti-cancer treatment: from pathobiology to bedside. Cancers (Basel). 2019; 11: 857.

29. Knochylska-Karawan Z. Stomatologia geriatryczna. Kraków: Collegium Medicum UJ, 1995; 21-23, 94.

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